For example, CPV can trigger host G1/S cell cycle arrest via the EGFR (Y1086)/p27 and EGFR (Y1068)/STAT3/cyclin D1 axis (Dai et al., 2020), and in the late stage of viral infection, nuclear assembly of the progeny capsids is accompanied by virus-induced cell cycle triggering host cell G2/M phase arrest (Adeyemi et al., 2010; Ruiz et al., 2011; Mattola et al., 2022). This evidence concerns the gene STAT3 and viral infectious disease.