Liu et al. (2019) found that the expression of TRiC/CCT subunit 3 (CCT3) was increased in liver cancer, and further studies showed that CCT3 could enhance the protein stability of yes-associated protein (YAP) and transcription factor CP2 (TFCP2) by reducing their ubiquitination. It has also been shown that TRiC/CCT chaperone proteins (CCT2 and CCT5) can control avian reovirus (ARV) replication by protecting the ARV outer capsid protein σC and inner core protein σA, as well as the non-structural protein σNS, from ubiquitin-proteasome degradation (Huang et al., 2022). Here, CCT2 is linked to liver cancer.