These results are in line with prior studies from our laboratory and other laboratories on the chronic phase of the LGI1-limbic encephalitis phenotype (Argyropoulos et al., 2019; Butler et al., 2014; Frisch et al., 2013; Malter et al., 2014; McCormick et al., 2016a, 2017, 2018; Miller et al., 2017), whereas more extensive hippocampal damage is often associated with a broader pattern of cognitive deficits (Aly et al., 2013; Hamann & Squire, 1997; Olson et al., 2006). This evidence concerns the gene LGI1 and Cognitive impairment.