This mutation set frequently includes a pair of RNF43 and BRAF mutations in MSI-Hi CRC, whereas the combination of APC, KRAS, and TP53 mutations is common in MSS CRC as explained (Bond et al. 2016; Yan et al.2017; Fennell et al. 2020; Salem et al. 2020). Here, APC is linked to colorectal carcinoma.