Furthermore, RNF43 has been reported to suppress not only Wnt signaling but also downstream of a famous tumor suppressor gene known to be a guardian of the genome, p53 (Shinada et al. 2011; Nailwal et al. 2015; Xie et al. 2015; Tsukiyama et al. 2020). Here, RNF43 is linked to neoplasm.