Locus intersections between high low-density lipoprotein (LDL) cholesterol and AD among two independent genome-wide association studies (GWAS) across 408,942 individuals with AD from ref. 32 and 94,595 individuals with high LDL cholesterol from ref. 33, respectively, identified multiple shared variants, including chr19:44892362(hg38):A > G (rs2075650) and chr19:44905579(hg38):T > G (rs405509). The gene discussed is LGR5; the disease is Alzheimer disease.