Given gene ALB roles in pathways such as heme biosynthesis (Reactome R-HSA-189445), HDL remodeling (Reactome R-HSA-8964058) and insulin-growth like factor regulation (Reactome R-HSA-8964058), prioritization of mechanistic hypotheses linking ALB-related pathways with the pathophysiology of EHR-derived predictors (congestive heart failure, malnutrition, HLD) can be explored in future studies. The gene discussed is INS; the disease is leukodystrophy.