In contrast, in lysates from Pmp22 transgenic rats (Pmp22tg) which model CMT1A (Sereda et al, 1996), the overexpression of PMP22 correlated with an increased abundance of PTEN and a decrease of the 70 kDa ribosomal S6 kinase (S6K) phosphorylation downstream of mTOR at postnatal day 6 (Figs. 1C,D and EV1B). Here, RPS6KB1 is linked to Charcot-Marie-Tooth disease type 1A.