Genetic and pharmacologic targeting of the PTEN/PI3K/Akt/mTOR signaling pathway was used as a potential therapeutic strategy in the peripheral neuropathies Hereditary Neuropathy with Liability to Pressure Palsies (HNPP) and Charcot Marie Tooth disease type 1A (CMT1A). The gene discussed is PTEN; the disease is Charcot-Marie-Tooth disease type 1A.