By contrast, genetic ablation of Aqp4 in mTECs was never sufficient to render Aqp4ΔTEC mice susceptible to experimental autoimmune encephalomyelitis (EAE) after immunization with AQP4(201–220) even under conditions of Treg cell depletion (Extended Data Fig. 6a–c). Here, AQP4 is linked to experimental autoimmune encephalomyelitis.