ISG15 and neoplasm: Six tumor-infiltrating CD4+ T-cell clusters (CD4+_FOXP3, CD4+_CCR7, CD4+_LMNA, CD4+_ISG15, CD4+_CXCL13 and CD4+_MKI67) were identified after data filtering, integration, unsupervised clustering and annotation (Fig. 7N, O; Supplementary Fig. 11D; Supplementary Table 4).