CD4 and breast cancer: Furthermore, the signatures of the CD4+_MKI67 population, the CXCL13+ Tht population identified by Cohen et al. [40] and the CD4+ T-cell population in CE9 identified by Luca et al. [19] were all enriched in the same region in a human breast cancer specimen according to analysis of an in situ spatially barcoded microarray (Supplementary Figs. 11F and 12A).