CD4 and neoplasm: Strikingly, in the tumor cell-associated antigen cross-presentation setting with Mel526 cell debris, both the proliferation and Granzyme B production of MART-126-35-specific CD8+ T cells and non-MART-126-35-specific CD8+ T cells were significantly compromised in the IFNB1 siRNA-transfected CD4+ T-cell condition (Fig. 4H–K).