ISG15 and breast carcinoma: In addition, the CD4+_ISG15, CD4+_MKI67 and IFN-I signatures identified in tumor-infiltrating CD4+ T cells (Supplementary Table 3) showed enrichment in the same tissue region in a human breast cancer specimen subjected to spatial transcriptomic profiling (10x Visium) (Supplementary Fig. 11F and G).