Here, we find that the Ki67+ cells among the CXCL13+CD4+ T cells in the TME are the IFNβ-producing cells, are enriched in the tumor-reactive gene signature reported by Lowery et al. [39], and positively correlate with the presence of similarly defined tumor-reactive CXCL13+CD8+ T cells. This evidence concerns the gene CXCL13 and neoplasm.