CXCL8 and cancer: Furthermore, onametostat treatment caused overall downregulation of the signalling pathways sustaining survival of the cancer cells, especially in reduced oxygenation (for instance, decrease in levels of Wnt receptor Frizzled FZD2 and telomerase TERT was significant in hypoxic conditions, while levels of C-X-C motif chemokine CXCL8 and various mitogen-activated protein kinase cascade members were decreased in both conditions).