While additional investigations are required to uncover how AKS-452 induces this omicron-specific neutralization potency, it may be reflected in conditions of immune imprinting caused by prior vaccination with WT whole SP antigen or infection in which a de novo induction of an anti-omicron SP/RBD cross-reactive population of B cells could be transiently induced by AKS-452, as demonstrated with other vaccine conditions4,6,27. The gene discussed is TFF2; the disease is infection.