The 10X Visium, 10X Chromium, and tDISCO analyses generated a list of interesting candidate transcripts that appeared to be differentially expressed in astrocytes proximal and distal to stroke injury, including the candidate genes, Apoe, Fabp5, Clu, Aldoc, and Cd81, (Fig. 5, Supplementary Fig. 9). The gene discussed is APOE; the disease is stroke disorder.