The genes Fabp5 (adjusted p-value = 7.63 × 10−171), Apoe (adjusted p-value = 3.87 × 10−82), Cd81 (adjusted p-value = 3.91 ×10−181), and Clu (adjusted p-value = 2.16 × 10−257) were also enriched in the putatively proximal cluster 6 identified in the smaller astrocytic dataset (Fig. 3C, Supplementary Data 1), contributing to the robust nature of these candidate genes in astrocytes present within the stroke infarct area. This evidence concerns the gene APOE and Stroke.