The 10X Visium, 10X Chromium, and tDISCO analyses generated a list of interesting candidate transcripts that appeared to be differentially expressed in astrocytes proximal and distal to stroke injury, including the candidate genes, Apoe, Fabp5, Clu, Aldoc, and Cd81, (Fig. 5, Supplementary Fig. 9). This evidence concerns the gene CLU and Stroke.