Other mutations, both in the unique N-terminal domain (D40G) and the C-terminal annexin core (R235Q), were identified in patients suffering from amyotrophic lateral sclerosis (ALS) and mutation carriers showed AnxA11 aggregates in spinal cord motor neurons and hippocampal neuronal axons indicative of misfolded and non-functional protein142. The gene discussed is ANXA11; the disease is amyotrophic lateral sclerosis.