Altered or mutant expression of several annexins has also been linked to human pathologies and the term ‘annexinopathies‘ has been coined, initially describing the overexpression of AnxA2 in patients suffering from acute promyelocytic leukemia (APML) and the reduction of AnxA5 on placental trophoblasts in antiphospholipid syndrome and preeclampsia patients124. This evidence concerns the gene ANXA5 and acute promyelocytic leukemia.