In the present study, we found that using AD risk factors such as age, ApoE ε4, biomarkers (amyloid β42 and pTau), and cognitive scores (CDR-SB, MMSE, and ADAS-cog) as stratification indices in stratified randomization could also reduce the allocation bias in CDR-SB changes to a certain degree. This evidence concerns the gene APOE and Alzheimer disease.