For a comprehensive comparison, stratified randomization using demographic information (age), biomarkers (ApoE ε4, Aβ42, and pTau), and cognitive scores (CDR-SB, the Mini–Mental State Examination [MMSE], and the Alzheimer’s Disease Assessment Scale–Cognitive [ADAS-cog]) as stratification indices was also simulated. Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.