AGT and acute kidney injury: In another post-hoc subgroup analysis of ATHOS-3 of patients with AKI requiring RRT at randomization, angiotensin II was associated with statistically significant benefits in both mortality and liberation from RRT [74], an effect felt to reflect angiotensin II’s ability to increase or preserve glomerular filtration through preferential vasoconstriction of the efferent renal arteriole.