However, the clinical significance of these observations remains unclear: while a meta-analysis of > 1,700 critically ill patients unexposed to angiotensin II reported a deep vein thrombosis (DVT) rate of 12.7% [69], subsequent observational studies of angiotensin II use reported rates of DVT of ≤ 5% [49, 52, 70]. This evidence concerns the gene AGT and deep vein thrombosis.