Further, antigen escape by lineage switch between TRBC1 and TRBC2 is an unlikely scenario especially in mature T-cell lymphomas such as PTCL and ATCL, where the malignant cells have already undergone TCRβ rearrangement and commitment to allelic exclusion21. This evidence concerns the gene TRBC1 and mature T-cell and NK-cell non-Hodgkin lymphoma.