IL6 and acute respiratory distress syndrome: Latent class analysis (LCA) of clinical and protein biomarker data has identified two subtypes of non-COVID acute respiratory distress syndrome (ARDS), termed “hyper-inflammatory” and “hypo-inflammatory,” the former characterized by elevated plasma levels of inflammatory biomarkers such as IL-6 and soluble TNF receptor 1 (sTNFR-1) and lower levels of bicarbonate and protein C [20].