We also investigated the dependency profile of BCL2 family proteins (BCL2, BCL2L10, BCL2A1, BCL2L1, and MCL1) in GBM within Cancer Cell Line Encyclopedia, and found that GBM cells show the greatest dependency on Bcl-xL (BCL2L1) for survival (Fig. 1G). This evidence concerns the gene MCL1 and glioblastoma.