Accumulation of amyloid-β and phosphorylated tau is a well-known neuropathological hallmark of AD [1] On the other hand, neuroinflammation, defined as an inflammatory response of the central nervous system (CNS), is mediated by activation of the innate immune system of the brain in response to various inflammatory challenges, including protein misfolding and aggregation, which are often found in neurodegenerative diseases, including AD [2–4]. This evidence concerns the gene MAPT and Alzheimer disease.