Ubiquilin2 and myotubularin-1 recognize vimentin for degradation in skeletal muscle cells to avoid proteotoxic aggregate formation [32].In breast cancer, FERM domain-containing protein 3 (FRMD3) interacts with ubiquitin protein ligase E3A (UBE3A) to induce vimentin proteasomal degradation [33]. Here, UBE3A is linked to breast cancer.