Moreover, scatter plots were constructed to further illustrate the correlation between SGOL1 and commonly studied ICIs, CD274 (PD-L1), CD276 (B7-H3), TIGIT, PDCD1, LAG3, HAVCR2, CTLA4, and BTLA, in ccRCC patients, and the results demonstrated a strong positive correlation between SGOL1 and ICI expression (Fig. 6C). Here, TIGIT is linked to nonpapillary renal cell carcinoma.