As the most common pathological type of RCC, ccRCC accounts for approximately 85% of new patients and is characterized mainly by the loss of the tumor suppressor Von Hippel Lindau (VHL) function, the mutations in the factors governing the hypoxia signaling pathway and intracellular lipid accumulation caused by unknown pathomechanisms [1, 2]. Here, VHL is linked to nonpapillary renal cell carcinoma.