Hence, we knocked down SGOL1 by transfecting 786-O cells with SGOL1 siRNA and overexpressed SGOL1 by transfecting SW839 cells with an SGOL1 overexpression plasmid to investigate the potential biological function of SGOL1 in ccRCC cells (Fig. 9A). Here, SGO1 is linked to nonpapillary renal cell carcinoma.