We found that age (HR = 1.687, CI = 1.098–2.592, P = 0.017), M stage (HR = 2.714, CI = 1.602–4.599, P < 0.001), histologic grade (HR = 1.700, CI = 1.033–2.799, P = 0.037), and SGOL1 expression (HR = 1.874, CI = 1.223–2.872, P = 0.004) were found to be independent risk factors for ccRCC (Supplementary Table 3). The gene discussed is SGO1; the disease is nonpapillary renal cell carcinoma.