IRF1 is a crucial regulator, the inflammation-driven activity of IRF1 and NF-κB promotes the reactivation of endogenous retrovirus K in motor cortical neurons of amyotrophic lateral sclerosis, and may play a role in the resistance of glioma to immune checkpoint blockade [44, 45]. This evidence concerns the gene NFKB1 and amyotrophic lateral sclerosis.