Ablation of NRG3 and ERBB4 leads to a reduction in the number of excitatory synapses on small parvalbumin-positive interneurons, altered short-term neuroplasticity, and disinhibition of the hippocampal network, which plays a critical role in intercellular communication in alzheimer’s disease [46]. The gene discussed is PVALB; the disease is early-onset autosomal dominant Alzheimer disease.