Frequent TP53 CNV loss occurred in cSCLC (43%, 13/30), 4/8 in ADC/SCC, and 1/7 in LCC/LCNEC, particularly in ADC/SCC (50%, 4/8) and the AS-SCLC component (88%, 7/8). The gene discussed is TP53; the disease is leukoencephalopathy with calcifications and cysts.