Conversely, in P6, a cluster of subclonal events in SCLC corresponded to clonal events in paired SCC (Fig. 4B), involving Notch signaling-related genes (DTX3 and SNW1), Ras protein signal transduction (AKAP13, ALS2, and GPR55), neuron projection, and certain cellular components (SCN1A, SCN2A, and KIF1A). The gene discussed is ALS2; the disease is small cell lung carcinoma.