CD8A and small cell lung carcinoma: A comparison of immune cell infiltration between SCLC and paired LCC/ADC/SCC is presented in Fig. 3D. Notably, immune-positive regulated immune cells in ADC/SCC exhibited significantly higher immune infiltration compared to paired SCLC, encompassing activated and immature B cells, macrophages, central memory (CM), and effector memory (EM) CD8+ T cells.