Conversely, in P6, a cluster of subclonal events in SCLC corresponded to clonal events in paired SCC (Fig. 4B), involving Notch signaling-related genes (DTX3 and SNW1), Ras protein signal transduction (AKAP13, ALS2, and GPR55), neuron projection, and certain cellular components (SCN1A, SCN2A, and KIF1A). This evidence concerns the gene SCN2A and small cell lung carcinoma.