RB1 and cervical squamous intraepithelial neoplasia: Furthermore, there was no significant difference in wGII between patients with RB1 inactivation and those with wild-type RB1 when considering concurrent TP53 inactivation (P = 0.22, Additional file 1: Figure S9B), underscoring the pivotal role of RB1 over TP53 in CIN.