To investigate the effect of ZSWIM4 in driving chemotherapy resistance, we selected two cell lines with low expression of this protein, IOSE-80 (human normal ovarian epithelial cells) and ES-2 (human ovarian clear cell carcinoma cells) cells (Additional file 1: Fig. S2A), to establish the ZSWIM4 overexpression models (Fig. 2A, Additional file 1: Fig. S2B). Here, ZSWIM4 is linked to ovarian clear cell cancer.