Despite the differences to our transgenic mouse model of BE with a progressive, IL-1β-driven esophagitis with dysplasia and metaplasia, in the surgically-induced model esophagitis and esophageal hyperplasia displayed a higher expression of PAR vs normal esophageal tissue, in addition to γH2AX and NF-κB [34]. This evidence concerns the gene NFKB1 and dysplasia.