The relative migration and invasion cell numbers with both EIF4A3 inhibition and overexpression hsa_circ_0005397 shown less compared with cells with only hsa_circ_0005397 overexpression (Fig. 5M), these results demonstrate that hsa_circ_0005397 may regulate the proliferation of HCC through EIF4A3. This evidence concerns the gene EIF4A3 and hepatocellular carcinoma.