Since SCD1 is downstream of PI3K/AKT/mTOR signaling, GPER1 must be involved in activation of the MAPK, PI3K/AKT, and Notch1 signaling pathways and promote NSCLC progression, indicating that GPER1 has a regulatory effect on SCD1 expression (Liu et al. 2015; Shen et al. 2021; Yi et al. 2020). This evidence concerns the gene NOTCH1 and non-small cell lung carcinoma.