NF1 and hepatocellular carcinoma: Although there are just a few studies on the molecular mechanisms of R-RAS2 function in human cancer cells, our results are in accordance with the previously shown increase in cell motility of hepatocellular carcinoma cells [54], migration of Nf1-null Schwann cells [55], and migration and invasion of breast epithelial cells [56], due to overexpression of wild-type R-RAS2.