NFIL3 and cancer: Based on the TCGA (The Cancer Genome Atlas) database (https://www.cancer.gov/tcga), the bZIP domain of NFIL3 harbors many hotspot disease mutations, including the E78G, R91C/H, R94H and R95Q mutations in the basic region, and the E111Q, A113T and A113V mutations in the leucine zipper (Fig. 5A).