TTN and dilated cardiomyopathy: In addition, the downstream loci c.10120A>T (p.Lys3374Ter), c.5383A>T (p.Lys1795Ter), and c.5047C>T (P.RG1683ter) of TTN gene have all been reported as pathogenic mutations of dilated cardiomyopathy in Clinvar (NM_001267550.2), so the TTNtv c.13254T>G may lead to TTN protein truncation changes, and then lead to dilated cardiomyopathy.