The authors consider adjuvant mitotane in patients with high-risk disease, including those with positive surgical margins, a ruptured capsule, large size (no specific cutoff is offered in the available treatment guidelines), and/or a high tumor grade (Ki-67 staining of >10%).47 A target mitotane level of 14-20 μg/mL should be reached. The gene discussed is MKI67; the disease is neoplasm.