UC-MSC treatment was associated with a statistically significant reduction in circulating pro-inflammatory mediators including TNF-α at 0-6, 7-24, 25-48, and 49-72 hours post sepsis induction; IL-1β at 0-6, 7-24, and 49-72 hours post sepsis induction; IFN-γ at 0-6 and 49-72 hours post sepsis induction; IL-6 at 0-6, 7-24, 25-48, and >72 hours post sepsis induction; and MCP-1 at 0-6 and 7-24 hours post sepsis induction. This evidence concerns the gene IL6 and Sepsis.