Hepatocyte transporter membrane trafficking, insertion, and retrieval is a dynamic process involving multiple mechanisms27 that are altered in NASH.45 Another proposed hypothesis for NASH-mediated MRP2 internalization is oxidative stress.45 Oxidative stress is predominantly experienced by pericentral hepatocytes in NASH.34 It is possible that observed impairments in pericentral BSEP and NTCP localization are influenced by oxidative stress. This evidence concerns the gene ABCB11 and metabolic dysfunction-associated steatohepatitis.