For example, decreased pericentral BSEPMZA could predispose individuals to BA-mediated DILI in zone 3 as acute BA-mediated hepatocellular and cholestatic DILI always appear in this region.49 The BSEPMZA data could be incorporated into quantitative systems toxicology models to optimize BSEP-mediated DILI predictions in the metabolic syndrome population.25 This evidence concerns the gene ABCB11 and metabolic syndrome.