Isolated periportal disease is rare in adult patients.35 OATP1B1, OATP1B3 and NTCP overall abundance were decreased in 1 NASH cohort.18 Considering these data, increased relative periportal OATP1B3 in NAFLD and I1 biopsies indicates less zone 2 and 3 protein, suggesting a weaker pericentral gradient for OATP1B3 in NAFLD compared to NDL. This evidence concerns the gene SLCO1B3 and metabolic dysfunction-associated steatohepatitis.