Isolated periportal disease is rare in adult patients.35 OATP1B1, OATP1B3 and NTCP overall abundance were decreased in 1 NASH cohort.18 Considering these data, increased relative periportal OATP1B3 in NAFLD and I1 biopsies indicates less zone 2 and 3 protein, suggesting a weaker pericentral gradient for OATP1B3 in NAFLD compared to NDL. The gene discussed is SLC10A1; the disease is metabolic dysfunction-associated steatotic liver disease.