MUTYH and cancer: Additionally, missense mutations and loss-of-heterozygosity in Ogg1 have been associated with increased risk of human cancer (Mahjabeen et al., 2012; Chevillard et al., 1998), and copy-number losses of either Ogg1 or Mutyh are linked to elevated rates of spontaneous C>A mutation in human neuroblastoma (van den Boogaard et al., 2021).