VWF and cardiomyopathy: Moreover, as mentioned above, the main function of VWF is to initiate platelet adhesion and that PECAM-1 plays an important role in the regulation of the thrombotic process, we have investigated the role of VWF and PECAM-1 as key factors in the microthrombi formation in the coronary circulation in the failing human hearts due to cardiomyopathies.