BCL6 and atherosclerosis: To study the role of Tfh in atherosclerosis, we first followed a BM reconstitution methodology in Ldlr−/− mice, described in a previously published report on the role of Tfh cells in atherosclerosis.7 We generated mice with T cell–specific conditional deletion (CD4Cre/+) of the Tfh lineage transcription factor Bcl6 (Bcl6flox/flox). We then reconstituted lethally irradiated Ldlr−/− mice with a BM containing 100% cells from CD4Cre/+; Bcl6flox/flox (that are unable to generate Tfh).