A notable hindrance in the regression of HCC after RT upon the induction of RECQL4 expression in immunocompetent C57BL/6 mice was observed (Figure3A), the degree of this impact differed from that observed in immunodeficient NSG mice (Figure 3B), suggesting that the immune system may be involved in RECQL4 function. The gene discussed is RECQL4; the disease is hepatocellular carcinoma.