RECQL4 and neoplasm: Owing to ICB treatment, Tpex cells have a stronger ability to proliferate and differentiate into Tex cells, enhancing immune responses.[43, 44] Therefore, we speculated that RECQL4 impairs the transformation of the radiation‐induced TME into a tumor‐killing ecological niche, which is detrimental to immune checkpoint inhibitor therapy and may lead to resistance to RT combined with immune therapy.