Previous studies have demonstrated that RT can activate the immune system against cancer cells, leading to regression of distant tumors with the same antigenic effect, a phenomenon known as the “abscopal effects”.[25] Due to these findings, an “abscopal effect” model was considered to investigate the impact of the intact immune system on RECQL4‐mediated HCC radiotherapy efficacy (Figure S3B, Supporting Information). The gene discussed is RECQL4; the disease is cancer.