CD8A and neoplasm: In other words, localized inflammatory responses caused by radiation can reset the interference between tumors and the immune system, induce immune stimulation signals to increase tumor antigen presentation, activate effector T cells, create an immune‐permissible TME, and enhance responsiveness to immunotherapy.[41] Recent studies have shown that exhausted T cells (Tex) promote MDSC differentiation, leading to an antigen‐presenting phenotype.[42] CD8+ Tex cells, which kill tumors, originate from precursor‐exhausted T cells (Tpex).