First, IR can cause acute tumor‐related death; Second, in the TME, tumor DNA and cyclic GMP‐AMP are released, leading to activation of the cGAS‐STING pathway.[40] However, RECQL4 reduces tumor cell damage, resulting in a reduction in dsDNA release and adaptive immune responses caused by cGAS‐STING activation in DCs. Here, RECQL4 is linked to neoplasm.