CD8A and small cell lung carcinoma: Although CD8 sorted GD2-2840z-CARTs exhibited slightly greater cytotoxicity against H446 cells than did GD2-2840z-CARTs (without CD8 sort), cytotoxicity against H69 and SCLC-J1 cells was not significantly enhanced (H69; 21.2% vs. 13.6%; P = 0.2326, H446; 21.2% vs. 13.3%; P = 0.0029, SCLC-J1; 5.6% vs. 5.2%; P = 0.9919 at an E:T ratio of 20:1; Supplementary Fig. S2D).