With cytotoxic function of GD2-2840z-CARTs enhanced by coblockade of PD-1 and TIGIT (Fig. 5E), even GD2-CARrejTs with low expression of TIGIT and PD-1 acquired robust antitumor effect against SCLC (Fig. 5F). Here, PDCD1 is linked to small cell lung carcinoma.