Therefore, we have investigated the effect of amyloid seeds, as initiators, and heparin, as surrogate for a generic physiological fibril‐stabilizer, on the fibrillogenesis of two TTR variants responsible for some of the most aggressive forms of cardiac amyloidosis, S52P (Stangou et al., 1998) and L111M TTR (Frederiksen et al., 1962). This evidence concerns the gene TTR and cardiac amyloidosis.