PARK7 and Parkinson disease: In this work, we showed that the lysine 182 (K182) residue of DJ‐1 undergoes N‐hcy, which attenuates its activity against oxidative stress and mitochondrial dysfunction in 1‐methyl‐4‐phenylpyridinium (MPP+)‐induced SH‐SY5Y cells and MPTP‐induced PD mice.