PTEN and cancer: ALDHpositive tumor initiating cells have been shown to involve EGR2 upregulation.[42] Meanwhile, EGR2 transactivates BNIP3L/BAK in PTEN‐induced apoptosis[43] and exerts growth‐suppressive effects.[44] Moreover, EGR2 binds ARF promoters and p16 to induce senescence.[45] EGR2 malfunctions are also known to be related to cancer.[46, 47]