Several of these TFs were also identified when comparing PDO versus PT and PDOX versus PT, respectively (Figure S13A, Supporting Information), including EVX2, reported to be methylated in lung cancer,[34] and SNAI1/2, involved in epithelial‐to‐mesenchymal transitions (EMT) and responsive to EGF.[35, 36] These TF footprints were further analyzed by TOBIAS BINDetect[37] (Figure S13B, Supporting Information). Here, EVX2 is linked to lung cancer.