Krüppel‐like family factors have been reported to regulate a multitude of cancer‐relevant processes.[38] KLF14 precludes KRAS‐associated cell growth and transformation,[38, 39] and loss of KLF14 can trigger PIK4‐mediated centrosome amplification to promote colon tumorigenesis.[40] KLF14 has also been associated with high‐density lipoprotein cholesterol levels and metabolic syndrome.[41] EGR2 might entail multifaceted roles in cancer. The gene discussed is KLF14; the disease is cancer.