DNMT3A and neoplasm: DNMT3A‐mediated de novo DNA hypermethylation plays an important role in regulating multiple biological processes, including embryonic development, somatic cell reprogramming, and even oncogenesis.[17] Although DNMT3A and its genetic mutations are well known in hematological malignancies,[18] the potential roles of DNMTA in solid tumors, especially in tumor aggressiveness, remain largely unknown.