Deregulation of the Hippo pathway results in the dephosphorylation and nuclear localization of YAP to control the expression of cell cycle regulators and accelerate the growth of tumor cells.[30] In the present study, we showed that DNMT3A interacts with YAP/TAZ but does not modulate YAP/TAZ expression or cytoplasmic sequestration, revealing a Hippo pathway‐independent role for YAP in recruiting DNMT3A access to specific genome locations. Here, DNMT3A is linked to neoplasm.