DNMT3A and neoplasm: To investigate whether the above results generated by DNMT3A are related to the aggressive signatures of GBC, we performed the Gene Set Enrichment Analysis (GSEA) of the transcriptome of GBC tumor tissues from our published GBC transcriptional profiles (GSE139682).[8a] GSEA results showed that gene signatures representing metastasis, especially epithelial‐to‐mesenchymal transition (EMT), were significantly enriched in patients with higher levels of DNMT3A expression than in those with lower expression of this gene (Figure 4a).