The same lack of specificity applies to other biomarkers, such as CXCL10, which is commonly associated with viral infections.[22, 36] Furthermore, uPA and sTREM2 have been, respectively, implicated in CNS malignancies and neurodegenerative diseases such as neuroblastoma and Alzheimer's disease,[37, 38, 39] which may lead to false‐positive results if used as standalone indicators of NS. Here, PLAU is linked to early-onset autosomal dominant Alzheimer disease.