The aim of this study was to investigate the production of epidermal growth factor, transforming growth factor-α and IL-8 in nasal mucosa irrigated with hypertonic 2.3 per cent sea water with the addition of algae (Undaria pinnatifida and Spirulina platensis) extracts, in comparison to isotonic 0.9 per cent sodium chloride solution in the reparative phase during the first two weeks after FESS for nasal polyposis, in relation to symptoms and local findings in the nasal cavity. This evidence concerns the gene CXCL8 and Nasal polyposis.