Compared with patients with NMAC, patients with MAC were more likely to have a tumor located in the proximal colon, a larger tumor diameter (p<0.01), more advanced T stage (p<0.01), higher frequency of metastasis (p=0.02), dMMR (p<0.01), and elevated preoperative CEA (p<0.01). The gene discussed is CEACAM5; the disease is neoplasm.