Tumor diameter, PNI, TNM stage, MAC phenotype, preoperative CEA, and CA19-9 were independent prognostic factors for OS, while tumor diameter, PNI, TNM stage, MAC phenotype, mismatch repair status, and preoperative CA19-9 were independent prognostic factors for CSS in patients with primary CRA. This evidence concerns the gene CEACAM5 and neoplasm.