NLRP3 and acute respiratory distress syndrome: In LPS/D-GalN induced ALI model, the inhibition of macrophage pyroptosis by Maresin 1(MaR1) leads to significant reductions in NLRP3 inflammasome expression, consequently suppressing GSDMD-N and IL-1β expression, effectively tempering macrophage pyroptosis, thereby alleviating the extent of liver injury in ALI (55).