This study is not designed to elucidate if changes in CD4 Tconv cells determine dysglycemia or rather dysglycemia induces CD4 Tconv cell skewing; however, considering that the natural history of T2D consists in the progression from a normoglycemic state to a transient phase of prediabetes preceding the development of full-blown disease,47 the homogeneity of CD4 Tconv cells infiltrating the VAT in patients with dysglycemia suggests that changes of CD4 Tconv cells may occur long before the development of T2D. Here, CD4 is linked to type 2 diabetes mellitus.