CD4 and cancer: An altered integrin expression profile was evident in PD-1+CD4 Tconv cells from OB-Dys, which included higher expression levels of ITGAX – enriched in T cells with high migratory potential31 – and ITGAV – associated with cancer progression32 – (Figure 5C), and lower expression of ITGA1, tissue-resident memory T cell marker33 (data not shown).