The deposited Aβ aggregates play a dual role in AD development, acting both as insoluble Aβ in conjunction with ganglioside GM1 and contributing to the formation of extracellular neuroinflammatory Senile Plaques (SP) and Neurofibrillary Tangles (NFTs) formed by tau protein hyperphosphorylation. The gene discussed is MAPT; the disease is Alzheimer disease.