Therefore, the reduced expression of the FXN gene and its protein frataxin, as observed in FRDA patients, has been associated with mitochondrial iron overload, reduced ATP production, oxidative stress, downregulation of antioxidant response element (ARE) -regulated genes and consequential cell death of sensory neurons in the dorsal root ganglia (DRG) and dentate nucleus (Nguyen et al., 2003; Moreno-Cermeño et al., 2010; Bayot and Rustin, 2013; Anjomani Virmouni et al., 2015; Jasoliya et al., 2017; Alsina et al., 2018). This evidence concerns the gene FXN and Friedreich ataxia.