STAT3 and glioblastoma: For example, a study demonstrated that miR-124 obtained from the U373MG glioblastoma cell line, in which an oncosuppressor is highly downregulated, exerted an antitumor effect by suppressing glioblastoma cell growth and inhibiting M2 microglial polarization by regulating the signal transducer and activator of transcription 3 (STAT3) signaling [55].