Subsequently, we discovered select CT-RCC HERV-E expression in ccRCC was regulated by transcription factor HIF-2α (known to be upregulated by Von Hippel-Lindau (VHL) tumor suppressor inactivation in ccRCC) and occurred only when the proviral 5’LTR was demethylated (Cherkasova et al., 2011). The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.