SLC8A1 and ischemia: Then, we assessed NCX1 levels in terms of mRNA and protein content to evaluate whether treatment with LNPs might abolish the NCX1 downregulation mediated by cerebral miR-103/107 rise during ischemia in temporoparietal brain cortex of ischemic rats.Indeed, following treatment of ischemic rats with LNPs 1, 3, and 4 encapsulating anti-miRNA103/107, the decrease of ncx1 mRNA induced by tMCAO was prevented (Figure 4C).